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Direct tissue temperature measurements suggested that therapeutic freezing may not have extended across the full diameter of the sciatic nerve, highlighting a key technical limitation that may explain the lack of clinical benefit

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E.KirchgessnerA.HoferM

doi: 10.1021/acs.jafc.0c05240 66 LiXLuZQiYChenBLiB

311 Such findings point towards different roles and different effects of reactive astrocytes at different times during the progression of autoimmune inflammation and suggest that different therapeutic approaches involving astrocytes may be required at different times

C.RossiterJ