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Notably, Ulk1 could phosphorylate Beclin1 and promote autophagy [50, 51]

Instead of broadly affecting many hormones, it focuses on metabolic processes linked directly to fat storage and breakdown

Kamei S, Chen-Kuo-Chang M, Cazevieille C, Lenaers G, Olichon A, Belenguer P, et al

Sources Novo Nordisk shares plunge after CagriSema obesity drug trial disappoints

doi: 10.3389/fnut.2026.1835714 Received 21 March 2026 Revised 30 April 2026 Accepted 06 May 2026 Published 21 May 2026 Volume 13 - 2026 Edited by Auriel A

88 A 16-week crossover trial in 36 women did not show any differences between hops (providing 100 mcg of 8-prenylnaringenin per day) and placebo in reducing menopausal symptoms after the first eight-week phase, but women assigned to placebo in the first phase and hops in the second phase had greater symptom relief at week 16 than those assigned to hops followed by placebo, indicating a strong placebo effect and a possible benefit from hops