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10.1016/j.tree.2020.10.015 112 Ruiz-AlonsoM.BlesaD.Diaz-GimenoP.GomezE.Fernandez-SanchezM.CarranzaF.et al (2013)

Studies show that this co-administration produces a significantly greater increase in GH than either peptide administered alonea synergistic, not merely additive, effect

The C-terminal amidation (NH) and strategic amino acid substitutions within the sequence contribute to its reported receptor binding selectivity and proteolytic stabilityproperties that are relevant for designing controlled in vitro assay conditions