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Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression

Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

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The three mice models were SAMP-1 female mice with accelerated aging and wild rats SAMR-1 and SHR (both female mice)

The honest answer: Retatrutide looks more powerful on headline weight-loss potential, but there is no true head-to-head trial against CagriSema yet