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J Neural Transm (Vienna) 112:16131624

The precipitation pH (pHp) These two properties of pKa and water solubility are brought together by combining them with Henderson Hasselbalch analysis to give the precipitation pH that allows us to determine the expected amount of niclosamide in solution across the whole pH range

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Furthermore, although toxicity tests on laboratory animals are the first choice to assess the adverse effects of chemicals causing human diseases, they do not always reflect human physiology and experimental settings, and do not reflect exposure to multiple chemical toxicants at low environmental levels during sensitive periods of development

Similarly, the ongoing effects of the hypertyrosinemia produced by the use of NTBC, as well as any associated complications with its use, including long-term behavioral and neuropsychological effects, remain to be better understood