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Importantly, this quiescent or slow-cycling state remains reversible: upon drug withdrawal or relief of selective pressure, DTP cells can rapidly re-enter the cell cycle and restore proliferative capacity, clearly distinguishing them from senescent cells or terminally arrested populations that display stable growth arrest and irreversible phenotypic commitment ( The third central mechanism involves chromatin remodeling and epigenetic plasticity

de Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruine AP, Goldbohm RA, van den Brandt PA, Weijenberg MP, van Engeland M

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Some common epitope tags include FLAG, Strep, Myc, hemagglutinin, protein A, His6-tag, calmodulin-binding protein, GFP and maltose-binding protein

It is one of the most-studied compounds in dermatology and matrix-biology research literature, frequently referenced in pre-clinical models of extracellular-matrix remodelling and gene-expression studies

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