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Several studies have suggested that the production of excess RONS and a disproportionate cellular antioxidant-oxidant balance have an important function in the pathogenesis of respiratory viral infections, such as SARS-CoV infections [7, 12, 19]

All TMT labeled samples were combined in equal amounts in a new tube (200 g) and were run on Mass spec after fractionation

doi: 10.3389/fmed.2021.762878 Received 23 August 2021 Accepted 06 December 2021 Published 03 January 2022 Volume 8 - 2021 Edited by Shu-Chuan Ho, Taipei Medical University, Taiwan Reviewed by Manish Bodas, University of Oklahoma Health Sciences Center, United States

Analysis was performed using Students t test, single comparison, or analysis of variance (ANOVA) test for multiple comparisons (one-way or two-way ANOVA followed by Tukeys or Bonferronis multiple comparisons test, respectively)

Research has demonstrated a significant association between vitamin D deficiency and the occurrence of depressive symptoms in elderly individuals, particularly during seasons with low sunlight exposure (80, 81) (Table 1)