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Gualano B, Ugrinowitsch C, Novaes RB, Artioli GG, Shimizu MH, Seguro AC, Harris RC, Lancha AH Jr

As a result, reviewers generally describe these findings as suggestive rather than definitive

EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells

Therefore, a combination of multiple strategies such as HFD+fructose and CD+HFD is widely employed to induce insulin resistance, dyslipidemia, ER stress, fibrosis and NASH (111)

Future studies will focus on the functional validation of these novel loci, including the integration of ocular-specific eQTL and gene expression data to elucidate the precise mechanisms, contribute to glaucoma pathogenesis

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Pablo Rivera-Fuentes reports financial support was provided by Swiss National Science Foundation.