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To address the second concern, i.e., that electron leak via the Tyr residue-10 of A42 was associated with the nitrone spin trapping to result in an EPR-detectable nitroxide and oxidative damage to and death of neurons, we repeated these experiments, comparing A42 with A42Y10F (113, 114)

Liu K, Li F, Sun Q, Lin N, Han H, You K, et al

J Clin Lipidol 1:191193 Gille A, Bodor ET, Ahmed K, Offermanns S (2008) Nicotinic acid: pharmacological effects and mechanisms of action