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It can inhibit the expression of CD36 and phosphorylated phospholipase C (p-PLC), improve abnormal lipid metabolism in T2DM mice, reduce excessive free fatty acid (FFA) uptake by renal cells, and exert anti-inflammatory and antifibrotic effects [143]

The demonstrated capacity for producing over a hundred tons of biomass per hectare per year under closed conditions [42] makes purslane an ideal candidate as the crop to produce its bio-molecules, reducing the risk associated with the fact it is a weed [43]

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Compared to AZEpaclitaxome-2 that has ~5 molar% DSPE-PEG 2K , this CD47p coating strategy significantly prolonged circulation time (by 1.67-fold) and delivered more drug to tumors (by 2.40-fold), while reducing the distribution to liver, spleen, lung and kidneys due to the MPS avoidance (Fig

The core clinical value of this drug class lies in their use as adjuncts to L-DOPA, significantly prolonging patients' "on" time, shortening "off" time, and potentially reducing the total daily dose of L-DOPA