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[DOI] [PubMed] [Google Scholar] Lee JM, Veres SP (2019) Advanced glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon

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Werme M, Thorn P, Olson L, Bren S

This kind of compounds shows a high specificity for IRAP against APN (Compound 8 IC 50 = 5.8 M) and according to docking studies, the inhibitor acts in a binding pocket close to the GAMEN loop without interacting with the zing atom, leading to uncompetitive inhibition, confirmed later on by kinetic studies