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Movement across the BBB occurs via transmembrane efflux pumps (Abbott et al., 2010) that transport molecules through endocytosis or through pores, carrier-mediated transport systems, or through direct permeation through the plasma membrane via lipophilic molecules (Banks and Kastin, 1992)

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J Physiol Paris 87:313327 Sikiric P, Seiwerth S, Brcic L, Sever M, Klicek R, Radic B, Drmic D, Ilic S, Kolenc D (2010) Revised Roberts cytoprotection and adaptive cytoprotection and stable gastric pentadecapeptide BPC 157

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Sublingual absorption delivers approximately 25 to 35% of the dose to your bloodstream, compared to approximately 80% for injection

With this characteristic, liposomes exhibit an excellent protective effect for the drug, as the aqueous phase stabilizes the polar segment, along with shielding the nonpolar segment of the drug