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The immunoconjugate of claim 33, wherein the drug comprises a pyrrolobenzodiazepine or a pyrrolobenzodiazepine dimer

Possible mechanisms of action of p53 in copper-induced cell death, also known as cuproptosis, include: 1

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2017), and there is substantial debate about the relevance to the toxicity observed in humans (Manov et al

3d,e and Supplementary Table 3)

Considering the current population of Munich and its area of influence as well as presuming that AHEM events follow a Poisson distribution with an average rate of occurrence equal to the incidence of vaccine-associated AHEM (independent of vaccine type, see above), the observed regional accumulation of three cases in the given time span would have a not inconsiderable probability of occurrence between 0.3 and 7%