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In the multivariate Cox regression analyses, crude favorable prognostic factors included a good ECOG-PS before pemetrexed exposure, BMI 20.66, FA level 5.55 ng/mL before premedication, higher serum RBP level before pemetrexed treatment, SI G) (Supplementary Table S5(a))

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The systematic analysis found that cartilage lesions complicated by limited progenitor cell activity and healing capacity, large size, high mechanical demands, local and systemic inflammation, or other systemic diseases are often excluded from treatment, likely due to complications and poor outcomes after cartilage restoration procedures in this context