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Numerous case studies report of severe impediments to the childs development as a result of B12 deficiency in the mother (48-50)

We further evaluated emerging therapeutic strategies that target copper homeostasisincluding chelators, chaperone inhibitors, and ionophoresand critically analyzed the translational challenges they face, such as off-target effects and preclinical model limitations

Campisi A, Sposito G, Pellitteri R, Santonocito D, Bisicchia J, Raciti G, Russo C, Nardiello P, Pignatello R, Casamenti F, Puglia C

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10.1016/j.jaci.2007.01.016 51 Klein GeltinkR