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Research conducted in vivo and in vitro has shown that acrolein causes oxidative stress, resulting in the rupture of cell membranes, DNA and mitochondria damage, endoplasmic reticulum (ER) stress, and the potential to initiate apoptosis (112, 113)

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4 ROS and antioxidants: dual roles in cellular physiology ROS processes that affect GSH homeostasis are summarized here, as this determines the activation threshold of GSH-responsive nanomaterials

The GSH system has 31 differential equations for the substrate concentrations in the rectangular boxes in Figure 1

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