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Pro-inflammatory cytokines, particularly IL-1, TNF-, and IL-6, are key mediators that stimulate chondrocytes to upregulate degradative enzymes such as matrix metalloproteinases (MMP-1, MMP-3, MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5)

compositions of the invention are pharmaceutically acceptable and comprise one or more active ingredients in admixture with one or more pharmaceutically-acceptable carriers or diluents and, optionally, one or more other compounds, drugs, ingredients and/or materials

Peroxidase enzymes are of considerable importance because they act as detoxifying agents for free radicals (e.g., glutathione peroxidase) and also facilitate the defense against invading pathogens (e.g., myeloperoxidase) (Strzepa et al., 2017)

EYE DOCTORS ARENT convinced that SS-31 lives up to the vision-changing claims

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