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Amylin analogs like cagrilintide work through the area postrema and nucleus tractus solitarius in the brainstem, a region that processes satiety signals through a completely separate neuronal network

To assess whether macrocycles and hHGF interacted with human, mouse and canine Met, each biotinylated macrocycle or hHGF was immobilized to a surface density of 200500 RUs (for biotinylated macrocycles) or ~2,200 (for biotinylated hHGF) RUs on a CAP sensor chip using a Biotin CAPture Kit (GE Healthcare), following the standard protocol

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PMID: 38980576 | doi:10.1007/s10787-024-01499-8 Sikiric P et al

REIMAGINE 1 a 40-week efficacy and safety phase 3 trial of once-weekly CagriSema 2.4 mg/2.4 mg and CagriSema 1.0 mg/1.0 mg versus placebo in 180 adults with type 2 diabetes inadequately controlled on diet and exercise

More rapid losses often reflect water rather than fat and may not persist