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DCs affected by HGF can induce an increase in T regulatory, interleukin 10 (IL-10), and transforming growth factor (TGF-)

Garbe C, Peris K, Hauschild A, Saiag P, Middleton M, Spatz A, Grob J-J, Malvehy J, Newton-Bishop J, Stratigos A, et al

This highlights the significant promise in concurrently focusing on c-MET and PD-1/PD-L1 for treating tumors with c-MET/PD-L1 positivity

Growth factor signaling, particularly involving pathways linked to vascular endothelial growth factor (VEGF) and fibroblast activity, appears to promote cell migration, collagen formation, and tissue regeneration

Four proline residues, including an unusual triple-proline sequence, confer resistance to enzymatic degradation

Journal (Journal of Applied Physiology, 2011, 110(3), 774780)