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Clin Cancer Res 1(18):1435-46, 2012

We recommend training beforehand: walking long distances, climbing stairs with a backpack, and acclimatizing in Cusco for 2 days before the start

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Additional oral calcium supplementation at a dose of 1.2 g/day when co-administered with metformin has previously shown to partially mitigate this effect of metformin suggesting its potential role in prevention of B12 deficiency