active white l glutathione bfad approved L-Glutathione Skin Whitening Capsules, Cream and Soap FDA Advisory No.2024-1483 || Public

This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier

Berg Glutathione is a fantastic option to explore

It seems that most enzymes are involved in drug resistance through the RTK pathway

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2017;68(1):224-32.e4

[PubMed] [Google Scholar] 130.Rossette M.C., Moraes D.C., Sacramento E.K., Romano-Silva M.A., Carvalho J.L., Gomes D.A., Caldas H., Friedman E., Bastos-Rodrigues L., De Marco L