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Nature 2021, 595 (7869), 625626

Scientists researching related fields benefit from the clarity research-use designations provide on experimental applications and regulatory compliance requirements

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It is however important to note that human clinical trials are still limited and side effects, as above, have been reported

Ingegnoli F, Ughi N, Crotti C, Mosca M, Tani C (2017) Outcomes, rates and predictors of transition of isolated Raynauds phenomenon: a systematic review and meta-analysis