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J.PulinilkunnilT.Villegas-MontoyaC.GarveyM

However, the AngII/AT 1 receptor system influences multiple functions beyond blood pressure, including body water balance, control of vasopressin and oxytocin release and sexual reproduction and behavior, thus undesirable drug-induced effects are possible

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

Ramezanian I, Baradaran E, Majidinia S, Ramezanian S, Jafari M

Its an FDA-approved injection used in people with type 2 diabetes