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3 University Paris Est Crteil, Crteil, France

A case study from PvSTATEM Byrne Isabel 1 , Fornace M Kimberly 2 , Emiru Tadele 3 , Mangahasimbola Tiandraza Reziky 4 , Demisse Mulugeta 3 , Abdo Melat 3 , Fikregabrail Aberra Kassa 3 , Bulto Mikiyas 3 , Rakotomanana Fanjasoa 4 , Randrianarisoa Malala Mirella 4 , Obadia Thomas 5 , Van der Pluijm Robert 5 , Randremanana Rindra 4 , Tadesse Fitsum 3 , White Michael 5 , Drakeley Chris 1 1 Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

However, this is challenged by the negative association between frequency of the cSHMT -C1420T variant and latitude documented in this study

A therapeutic switch was indicated in 13 patients (60%): 5 times for primary failure, 4 times for secondary failure, and 4 times after occurrence of adverse effects

Li X, Chu Y, Ma R, Dou M, Li S, Song Y, et al

Earlier, Liang et al