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In response to insulin stimulation, AKT phosphorylates tuberin (TSC 2), allowing its dissociation from the lysosome and for Rheb activation of mTORC1 (206)

Clinical studies specifically evaluated markers of carbohydrate metabolism including fasting glucose, insulin levels, hemoglobin A1c (HbA1c), and insulin sensitivity indices

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Drug Interactions 7.1 Moderate and Strong CYP3A4 Inhibitors A strong CYP3A4 inhibitor has been shown to increase lomitapide exposure approximately 27-fold [see Clinical Pharmacology (12.3)]

Ann N Y Acad Sci (2016) 1372:5364

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