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1 Deficiencies of methylfolate and vitamin B12 can lead to decreased SAMe levels, which has been associated with both mental illnesses such as depression and neurodegenerative disorders such as dementia

However, lithium has other clinical effects that may be partially independent of each other (Bojja et al

Beneficial metabolites were increased in the liver via the gut-liver axis, preventing the occurrence of T2DM (166)

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Abbreviations CNS: Central Nervous system CSF: Cerebrospinal fluid MLT: Magnesium-L-Threonate MAT: Magnesium-Acetyl-Taurate NMDA: N-methyl-D-Aspartate BDNF: Brain derived neurotropic factor CREB: cyclic AMP response element binding protein cAMP: cyclic adenosine monophosphate PFC: Prefrontal cortex MBP: Myelin basic protein ROS: Reactive oxygen species Nrf2: Nuclear erythroid related factor-2 HO-1: Haemooxygenase-1 PSD-95: Post synaptic density protein-95 Mg 2+ : Magnesium BBB: Blood brain barrier TCA: Tricarboxylic acid ADP: Adenosine di phosphate RBC: Red blood cell AD: Alzheimers disease CBC: Complete blood count WBC: White blood cell GABA: Gamma-amino-butyric acid SOD: Superoxide dysmutase GSH: Reduced Glutathione ETC: Electron transport chain DNA: Deoxyribonucleic acid ATP: Adenosine-tri-phosphate OGDH: Oxoglutarate dehydrogenase H&E: Hematoxylin and Eosin LFB: Luxol fast blue CoQ10: Coenzyme-Q10 RNA: Ribonucleic acid RRT: Rota-rod test GST: Grip strength test OFT: Open-field test MWM: Morris water maze EPM: Elevated-plus maze OD: Optical density ELT: Escape latency TSTQ: Time spend in target quadrant HB: Haemoglobin EDTA: Ethylenediamine tetraacetic acid ELISA: Enzyme linked immunosorbent assay ETC: Electron transport chain NADH: Nicotinamide adenine dinucleotide hydrogenase PBS: Phosphate buffer saline SD: Standard deviation References Abumaria, N., Yin, B., Zhang, L., Li, X