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Indeed, mucosal GSH depletion for a prolonged period of time (35 days) induced by diverse agents, such as BSO or DEM, results in severe degeneration of intestinal mucosal epithelial cells (Martensson et al, 1990

These changes in intracellular GSH levels affect key biological processes, including signal transduction, cell survival, proliferation (167) and various forms of cell death (168,169)

Therefore, it has been suggested to use the terms primary organic or primary psychogenic ED

Considering that CHAC1 is responsible for glutathione degradation and GLRX is the most well-studied catalytic enzyme for deglutathionylation, we examined the expression levels of CHAC1 and GLRX in these cells

7 and 8, respectively, and the kinetic parameters in Table 2 demonstrate tight and stable binding of CspZ to the immobilized aptamers

10.1085/jgp.117.3.253 J