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For example, if a phase I metabolite cant be cleared out quickly enough with phase II conjugation, then it can cause oxidative stress

Statistical analyses Statistical analyses were performed using SPSS 19.0 software

While it may produce somewhat less weight loss than injectable semaglutide or tirzepatide, it represents a scientifically validated needle-free option

Lancet (2015) 386:98394

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However, because this evidence comes from a preclinical mouse study rather than a human clinical trial, these findings should be interpreted cautiously and should not be used to support direct clinical recommendations for patients with T2DM (74)