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In addition to its role in redox buffering, GSH is a regulator of redox-dependent signaling and post-translational modification

In addition, , -unsaturated aldehydes and MDA can undergo nucleophilic attack at their carbonyl group to form a Schiff base with the -amino group of Lys ( Figure 1 Of note, although lipid peroxidation is the canonical source of PC, alternative pathways have also been observed

doi: 10.1152/ajpcell.1995.269.5.C1112

Genetics of Inflammatory Bowel Diseases

Given the pivotal role of PMN-MDSCs in lipid peroxidation-mediated immunosuppression and the resistance of neutrophils/PMN-MDSCs to ferroptosis, these cells pose a significant challenge in combining ferroptosis induction with immune checkpoint inhibition in cancer therapy

The classic mechanism of acetaminophen hepatotoxicity is that its reactive metabolite, N-acetyl-p-benzoquinoneimine (NAPQI), depletes GSH and then covalently binds to proteins