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Metabolomic profiling revealed significant deviations in liver metabolic profiles of the 20% WFBG group compared to the control group, indicating profound metabolic reprogramming

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Moreover, prophylactic treatment with either sildenafil or tadalafil improved cardiac contractile function and survival by attenuating doxorubicin-induced apoptosis and cardiac oxidative stress without interfering with the antitumor efficacy of doxorubicin in both in vitro and in vivo tumor models [161,162]

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Mitochondrial disorders in humans are genetically transmitted and caused by abnormal mitochondrial DNA, affecting nearly every medical condition [23]