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In vivo rodent studies have used continuous subcutaneous infusion via osmotic minipump and once-daily subcutaneous injection

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In mice, 125 I-labeled SOD1-containing nanoparticles display increased stability in blood and in the brain, and improved accumulation in brain tissues, in comparison with non-cross-linked complexes and native SOD1 (Klyachko et al., 2012)

However, some patients experience nausea as a temporary side effect, which may be less disruptive if it occurs during morning hours when food intake is lighter

& Oshima, J

3) (Glorieux and Calderon 2017)