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For topical applications, mild irritation, redness, or itching at the application site are the most commonly reported observations

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Additionally, this group demonstrated significant decreases in blood cadmium levels and in the following enzymes: alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase

Jellin JM, Batz F, Hitchens K

The lack of protective mucin and antimicrobial factors will therefore lead to increased frequency of bacteria penetrating into microvillous surface of enterocytes (Olsen et al., 2002

And that's because the main difference is that you're heating your body up through thermal radiation versus the ambient air