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En los ejemplos concretos del presente documento, Los polipptidos de FX modificados proporcionados en el presente documento, incluido el F x zimgeno modificado o FXa, tienen al menos una sustitucin de aminocido en un polipptido de FX sin modificar que es una sustitucin con S en una posicin que corresponde a la posicin 196

10.1161/CIRCIMAGING.123.015490 Summary Keywords -thalassemia, iron overload, myocardial injury, treatment, early identification Citation Fu C and Yang X (2025) Cardiac injury caused by iron overload in thalassemia

In addition, dysfunction of the Xc- system in ferroptosis leads to increased Glu concentration, causing neuroexcitotoxicity

The detrimental effect of oxidative stress is usually accompanied by changes in antioxidant defense mechanisms, with the alterations in antioxidant enzymes expression/activities during MASLD development and progression reported in many clinical and experimental studies