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Systemic inflammation increases intestinal permeability during experimental human endotoxemia

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Discontinuation Rates Discontinuation rates due to adverse events in the Phase 2 trial were dose-dependent, ranging from approximately 6% in the 1 mg arm to 16% in the 12 mg arm

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Consider increasing when Side effects are mild and controlled Appetite suppression is incomplete most of the week Weight trend has been flat for 34 consecutive weeks Consider holding when Nausea, reflux, constipation, or fatigue is lingering You are already getting full faster and eating less Weight is still trending down, even slowly We share the journey with the patient