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Sublingual administration of the extract significantly increased blood flow in both normal and ischemic conditions without altering systemic blood pressure or intraocular pressure, suggesting localized vascular effects

These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

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