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A significant association was found among Asian, Hispanic, or Latin population, middle-aged, and elderly people

According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects

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These complementary activities can either enhance or diminish the effectiveness of the injections, depending on how well they are aligned with the individuals health goals

The mechanism is hypothesized to involve enhanced Schwann cell function and axonal sprouting, potentially via the growth factor pathways already implicated in its other activities

For most patients, it resolves substantially after the first few weeks of a given dose