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Seek immediate medical attention for: Severe, persistent abdominal pain, especially if different from typical IBS pain or radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate fluid intake Signs of dehydration (decreased urination, dizziness, extreme thirst) Severe constipation lasting more than 3-4 days without bowel movement Blood in stool or black, tarry stools Yellowing of skin/eyes, right upper quadrant pain (possible gallbladder disease) Markedly reduced urination (possible acute kidney injury) Fever accompanying gastrointestinal symptoms Neck mass, difficulty swallowing, persistent hoarseness (thyroid concerns) Allergic reactions (rash, itching, swelling, severe dizziness) Scheduled follow-up should occur within 4-6 weeks of initiating therapy and after each dose escalation

One possibility is that SyeA interacts with host proteins involved in the lysosomal degradation process 50

doi: 10.1016/j.cellsig.2023.111013 90 MuhammadJSEladlMAKhoderG

Thyroid Tests

A clinico-pathologic correlation is often required to ensure accurate diagnosis of systemic causes of diffuse pigmentation

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