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They are fundamentally different systems

doi: 10.1016/0378-8741(91)90187-I

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Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man

The rest of the mice receive 5-FC (500 mg/kg/dose, IP, BID) for 4 consecutive days, plus Lomustine at day 1 (Lomustine (CCNU) Day 1 + 5-FC) or day 43 (Lomustine (CCNU) Day 43 + 5-FC)