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In the field of future mitochondrial-targeted drug development, several challenges remain

While protection against ferroptosis did not differ between apoE isoforms in vitro, other features of 4 carriers, such as low abundance of apoE protein and higher levels of polyunsaturated fatty acids (which fuel ferroptosis) could mediate the 4 alleles heighted risk of AD

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Abstracts were then scanned for relevance to the research question based on the inclusion and exclusion criteria for each review, as outlined below

To view a copy of this licence, visit About this article Cite this article Yadav, V., Sahoo, S., Malhotra, N