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These findings underscore that GSH regulates ferroptosis not only through peroxide detoxification but also by coordinating iron trafficking and Fe-S cluster integrity, thereby coupling redox defense to core metabolic fitness

Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells

Reduction of the roGFP2 disulfide occurs via a monothiol mechanism and involves a ternary complex with GSH and PfGrx

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In addition, GSH depletion induced SIPS, as evidenced by increased percentage of the senescence-associated -galactosidase-positive cells, increased senescence-associated heterochromatin foci (SAHF), as well as cell cycle arrest at the G1 phase

Ivanova M, Venetis K, Guerini-Rocco E, Bottiglieri L, Mastropasqua MG, Garrone O, Fusco N, Ghidini M