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Thus, this study aims to: 1) deepen the impact of PNPLA3 variation on mitochondrial function by overexpressing the I148M protein in HepG2 and Hep3B cells, to force the effect or introduce the mutation, respectively

Advise pregnant women using opioids for an extended period of time of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available (see PRECAUTIONS, Information for Patients and Pregnancy)