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Description

The mRNA transcripts of the GCLC subunit of glutamate cysteine ligase, which is the rate-limiting enzyme in GSH biosynthesis, as well as SLC7A11 which encodes the cystine/glutamate antiporter xCT, are previously unidentified targets for the RIDD activity of IRE1

SCD3 and MC5R: TaqMan Real Time PCR

Weis, S., Cui, J., Barnes, L

Moreover, the discovery challenges traditional views of CysLT-mediated inflammation and may help explain the effectiveness of current therapies that target these pathways