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PMC 4336627

Nassar GN, Leslie SW

The ketone body metabolite -hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation

There is no ramp-up phase and no dose escalation

Similarly, mitochondrial injury was evident by enhanced mitophagy via the regulation of Beclin1, Park2, LC3, and p62 levels in H 2 O 2 -induced proximal tubular epithelial cells [90,91]

These antioxidant systems include the GPX4 system, free radical scavenging antioxidant systems (such as the FSP1-COQH2 system, DHODH-CoQH2 system, and GCH1-BH4 system), and membrane repair systems ( Figure 1 )