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However, it is unknown if DCP is involved in exposing immune checkpoint expression that may affect cancer response to ICB

662,663,664 Gapmer oligonucleotides complementary to the adenine-adenine-guanine repeat sequence within the Frataxin gene have shown a higher efficacy in activating Frataxin RNA and protein expression

doi: 10.1126/sciadv.abg4302 38 ParkerJLDemeJCKolokourisDKuteyiGBigginPCLeaSMet al

All these data suggest that circadian clock components also affect tumor escape mechanisms and, therefore, could be responsible for the induction of cold tumors and the failure for current immunotherapies

We acknowledge that this study has some limitations

Hassett, A