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We also extend our appreciation to the reviewers and editors for their time, expertise, and constructive feedback, which have significantly improved the quality of this work

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Taken together, these data indicate a bottleneck in GSH production, particularly at the step catalyzed by glutamatecysteine ligase, catalytic subunit (GCLC) (Fig 2B)

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Therefore, it is likely that hypoxia can have a positive effect on TIL effector functions in tumors

Hypoglycemia becomes more likely, very in fasted states, and other effects such as fluid retention may become more apparent