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While this can be beneficial for drugs with low bioavailability or metabolic stability, this pharmacokinetic alteration can have a negative impact on drugs with an extremely narrow therapeutic index, such as captopril, lisinopril, and digoxin ( 14 The strengths and the weakness The present study includes both in vivo and in vitro experimental and clinical trials, which can provide a comprehensive overview of the mechanism and function of the most essential and promising flavonoids, resulting in a potential perspective for future researchers