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Highly lipophilic cationic molecules can easily traverse through hydrophobic lipidic bilayer membrane owing to cationic charge delocalisation

Even the recommended dose of 4 g/day for two weeks can elevate liver enzymes like ALT to three times the normal limit in about one-third of patients 59

At the methodological level, isotope tracing technologies can directly resolve actual metabolic flux changes, single-cell and spatial multi-omics can help identify cell-cell interactions and substrate competition in the tissue microenvironment, and genome-scale metabolic modeling can be used for priority ranking and assessment of targetability

10.3390/ijms23073779 103 WangM.LiS.WangY.ChengH.SuJ.LiQ