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Yuan H, Hansen KB, Vance KM, et al

ATP6AP1 KO cells exhibited an increased m compared to WT cells, which was further elevated by ACT treatment (Figs

& Wortis, H

It is neither sweet, salty , nor sour

The combination of these findings positioned NNMT as a candidate metabolic-disease and metabolic-aging research target, motivating development of selective small-molecule inhibitors including 5-Amino-1MQ