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This is particularly notable when compared to weight loss seen with either drug aloneSemaglutide alone resulted in about a 5.1% reduction in weight, while Cagrilintide alone resulted in around 8.1% Ready to Take Control of Your Weight

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Health alert Status: Active Date issued: 19 June 2026 Issued by: Dr Caroline McElnay, Chief Health Officer Issued to: Health professionals and the Victorian community Key messages The department has been notified of six cases of acute liver toxicity associated with an unapproved peptide product in Australia, labelled Retatrutide

DOI: 10.1371/journal.pone.0123861

If weight loss has plateaued or side effects are limiting progress, your clinician can evaluate whether a dosing adjustment or broader treatment plan modification is appropriate