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Outcomes covered biologic/surrogate (e.g., proteinuria, estimated glomerular filtration rate [eGFR] slope) and hard endpoints (kidney failure, major cardiovascular events, fractures, mortality)

Further analysis of these interacting proteins indicated that they are mainly involved in metabolic process (228 proteins) followed by transportation (59 proteins)

However, individual results may vary due to factors such as starting weight, metabolism, and adherence to the program

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smegmatis the SSA pathway depends on the RecBCD helicase-nuclease

The addition of the neddylated CULLIN4-RBX1 complex did not enhance the ubiquitination reaction (Fig